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[Relationship between ATP-binding cassette transporter 1 R219K genetic variation and blood lipids].
Zhao, Shui-Ping; Xiao, Zhi-Jie; Li, Quan-Zhong; Nie, Sai; Tan, Li-Min; Jiang, Bo; Wu, Jun.
Afiliación
  • Zhao SP; Department of Cardiology, Xiangya Second Hospital, Central South University, Changsha 410011, China.
Zhonghua Yi Xue Za Zhi ; 84(17): 1421-5, 2004 Sep 02.
Article en Zh | MEDLINE | ID: mdl-15500734
OBJECTIVE: To investigate whether ATP-binding cassette transporter 1 (ABCA1) R219K genetic variation is correlated with blood lipids. METHOD: Specimens of peripheral blood were collected from 692 patients with cerebral apoplexy, aged 62 +/- aged 12, and 352 sex- and age-matched persons without cardio-cerebro-vascular disease. Polymerase chain reaction-restricted fragments length polymorphism (PCR-RFLP) was used to determine the ABCA1 genotype: RR type (177 bp), RK type (177 bp, 107 bp, and 70 bp); and KK type (107 bp and 70 bp). The RR and KK type products were sequenced. RESULTS: The level of HDL-C showed an upward trend in the sequence of RR, RK, and KK genotypes with a significant difference between RR genotype (1.3 mmol/L +/- 0.4 mmol/L) and KK genotype (1.4 mmol/L +/- 0.4 mmol/L), especially in the males. The levels of TG tended downward in the sequence of RR, RK, and KK genotypes, however, without a significant difference between any 2 genotypes. Linear regression analysis showed that the HDL-C level was positively correlated with age in the noncarriers of ABCA1R219K genetic variation (RR genotype), and the TC level was negatively correlated with age in the carriers (RK + KK genotype). In the cohort aged
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Trastornos Cerebrovasculares / Transportadoras de Casetes de Unión a ATP / Hiperlipidemias / HDL-Colesterol Límite: Aged / Female / Humans / Male / Middle aged Idioma: Zh Revista: Zhonghua Yi Xue Za Zhi Año: 2004 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Trastornos Cerebrovasculares / Transportadoras de Casetes de Unión a ATP / Hiperlipidemias / HDL-Colesterol Límite: Aged / Female / Humans / Male / Middle aged Idioma: Zh Revista: Zhonghua Yi Xue Za Zhi Año: 2004 Tipo del documento: Article País de afiliación: China Pais de publicación: China