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Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging.
Popovich, I G; Zabezhinskii, M A; Anisimov, V N; Kovalenko, A L; Petrov, A Yu; Semenchenko, A V; Yashin, A I.
Afiliación
  • Popovich IG; Department of Carcinogenesis and Oncogerontology, N N Petrov Institute of Oncology, Ministry of Health of Russian Federation, Restock.
Bull Exp Biol Med ; 136(6): 595-8, 2003 Dec.
Article en En | MEDLINE | ID: mdl-15500082
Treatment of female SAMP-1 mice with Neuronol (drug containing succinic acid) given with drinking water starting from the age of 2 months during the whole life prolonged the lifespan and markedly reduced mortality of animals aged 1.5-2 years. Neuronol inhibited the development of spontaneous tumors, primarily lymphomas, and significantly prolonged lifespan in mice with tumors. Long-term treatment with Neuronol had no pathological side effects. Our experiments demonstrated geroprotective and anticarcinogenic activity of Neuronol and safety of its long-term use.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Succinatos / Envejecimiento / Anticarcinógenos / Ácido Succínico / Longevidad / Neoplasias Experimentales Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2003 Tipo del documento: Article Pais de publicación: Estados Unidos
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Succinatos / Envejecimiento / Anticarcinógenos / Ácido Succínico / Longevidad / Neoplasias Experimentales Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2003 Tipo del documento: Article Pais de publicación: Estados Unidos