Direct inner ear infusion of dexamethasone attenuates noise-induced trauma in guinea pig.
Hear Res
; 196(1-2): 58-68, 2004 Oct.
Article
en En
| MEDLINE
| ID: mdl-15464302
The protective effect of dexamethasone (DEX) against noise-induced trauma, as reflected in hair cell destruction and elevation in auditory brainstem response (ABR) sensitivity, was assessed in guinea pigs. The animals were administered DEX (1, 10, 100, and 1000 ng/ml) or artificial perilymph (AP) via a mini-osmotic pump directly into scala tympani and, on the fourth day after pump implantation, exposed to 120 dB SPL octave band noise, centered at 4 kHz, for 24 h. Animals receiving DEX demonstrated a dose-dependent reduction in noise-induced outer hair cell loss (significant at 1, 10 and 100 ng/ml DEX animals compared to AP control animals) and a similar attenuation of the noise-induced ABR threshold shifts, observed 7 days following exposure (significant at 100 ng/ml DEX animals compared to AP control animals). These physiological and morphological results indicate that direct infusion of DEX into the perilymphatic space has protective effects against noise-induced trauma in the guinea pig cochlea.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dexametasona
/
Glucocorticoides
/
Pérdida Auditiva Provocada por Ruido
Límite:
Animals
Idioma:
En
Revista:
Hear Res
Año:
2004
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Países Bajos