The Beijing genotype is emerging among multidrug-resistant Mycobacterium tuberculosis strains from Germany.
Int J Tuberc Lung Dis
; 8(9): 1107-13, 2004 Sep.
Article
en En
| MEDLINE
| ID: mdl-15455596
SETTING: Germany, 1995 to 2001. OBJECTIVE: To determine the genetic relationship of 451 multidrug-resistant (MDR) Mycobacterium tuberculosis strains from Germany and to identify strains of the Beijing genotype. DESIGN: All strains were analysed using IS6110 fingerprinting and a cluster analysis was performed. Clustering of isolates was used as a measure for recent transmission. RESULTS: Two hundred and fourteen of 433 strains (49.4%) with more than four IS6110 copies formed 46 fingerprint clusters comprising two to 32 patients. Transmission links based on classical epidemiological data could be established for 39 cases (18.2%) and in 14 clusters (30.4%), and included three cases of exogenous reinfection with MDR strains. One hundred and seventy-five strains (38.8%) were of the Beijing genotype with an increasing annual proportion from 19.2% in 1995 to 58.3% in 2001. About 70% of these patients had an indication of foreign birth, mainly the former Soviet Union. CONCLUSION: Transmission of MDR strains seems to be contributing to the spread of MDR-TB in Germany, and exogenous reinfection with MDR strains must be considered as a possible cause of treatment failure. A high proportion of these MDR strains is probably carried over from the former Soviet Union, and strains of the Beijing genotype represent an increasing cause of MDR-TB in Germany.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tuberculosis Pulmonar
/
ADN Bacteriano
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Resistencia a Múltiples Medicamentos
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Mycobacterium tuberculosis
Tipo de estudio:
Observational_studies
Límite:
Adolescent
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Adult
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Child
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Female
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Humans
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Infant
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Male
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Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Int J Tuberc Lung Dis
Año:
2004
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Francia