Sculpting the proteome with AAA(+) proteases and disassembly machines.
Cell
; 119(1): 9-18, 2004 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-15454077
Machines of protein destruction-including energy-dependent proteases and disassembly chaperones of the AAA(+) ATPase family-function in all kingdoms of life to sculpt the cellular proteome, ensuring that unnecessary and dangerous proteins are eliminated and biological responses to environmental change are rapidly and properly regulated. Exciting progress has been made in understanding how AAA(+) machines recognize specific proteins as targets and then carry out ATP-dependent dismantling of the tertiary and/or quaternary structure of these molecules during the processes of protein degradation and the disassembly of macromolecular complexes.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptido Hidrolasas
/
Adenosina Trifosfato
/
Adenosina Trifosfatasas
/
Proteoma
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos