Responses of cultured mammalian cells to prolonged low dose rate gamma irradiation.

Kal, H B; van Rongen, E; Welleweerd, J

Kal, H B; van Rongen, E; Welleweerd, J.

Afiliación

Kal HB; Institute of Applied Radiobiology and Immunology TNO, Rijswijk, The Netherlands.

Strahlenther Onkol ; 168(2): 111-6, 1992 Feb.

Article en En | MEDLINE | ID: mdl-1542846

RESUMEN

Experiments were performed to verify the finding of others that prolonged irradiation caused sudden death of cells. Continuous irradiation (dose rate 0.09 Gy/h) was applied to the R-1, RUC-2, V79 and T-1g cells for up to 140 days. End points were: population growth rate, plating efficiency and radiosensitivity. The population doubling times were increased and plating efficiencies decreased; cell survival after single doses at acute dose rate were lower than that of control cells. Part of the cell parameters returned to control values within three weeks after prolonged irradiation had been terminated. Sudden death after prolonged exposure was not observed.

Asunto(s)

Supervivencia Celular/efectos de la radiación; Animales; Muerte Celular/efectos de la radiación; Línea Celular; Radioisótopos de Cesio; Cricetinae; Rayos gamma; Ratas; Factores de Tiempo; Células Tumorales Cultivadas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Supervivencia Celular Límite: Animals Idioma: En Revista: Strahlenther Onkol Asunto de la revista: NEOPLASIAS / RADIOTERAPIA Año: 1992 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania

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