Human papillomavirus infection and loss of heterozygosity in esophageal squamous cell carcinoma.
Cancer Lett
; 213(2): 231-9, 2004 Sep 30.
Article
en En
| MEDLINE
| ID: mdl-15327839
The incidence/mortality rates of esophageal squamous cell carcinoma (ESCC) vary widely in different parts of China. Human papillomavirus (HPV) infection is considered a possible risk factor. Loss of heterozygosity (LOH) analysis on 87 ESCC specimens collected from three different areas of China showed lower frequency of LOH at marker D3S1621 in Linxian, an area with exceptionally high incidence of ESCC but low HPV infection rate. HPV-positive ESCC from Hong Kong, but not Sichuan, had higher frequency of LOH at D5S82 (APC, MCC), D6S497 (p21/Waf-1, HLA) and D13S260 (BRCA2) than HPV-negative samples. Our results suggest that different genetic pathways of carcinogenesis may be associated with geographic differences in risk factors.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Papillomaviridae
/
Neoplasias Esofágicas
/
Carcinoma de Células Escamosas
/
Pérdida de Heterocigocidad
/
Infecciones por Papillomavirus
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Cancer Lett
Año:
2004
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Irlanda