Styrene 7,8-oxide induces mitochondrial damage and oxidative stress in neurons.
Toxicology
; 201(1-3): 125-32, 2004 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-15297027
Styrene 7,8-oxide (SO) is the main metabolite of styrene, a neurotoxic compound used industrially. Neurons exposed to SO undergo apoptosis with characteristic features including chromatin rearrangements and caspase activation. We report that the execution phase of apoptosis induced by SO (0.3 mM) in SK-N-MC neurons is triggered by translocation of apoptogenic factors (e.g., cytochrome c) into the cytosol. In addition, mitochondria exhibit lower Ca2+ capacity and loss of mitochondrial membrane potential (DeltaPsi). Lipid peroxidation, measured as thiobarbituric acid reactive substances (TBARS), is increased after 12 h. Pre-treatment with the antioxidant MnTBAP (100 microM) prevents the decrease of Ca2+ capacity, cytochrome c release, activation of caspases, exposure of phosphatidylserine and cell death. Hence, the neurotoxic effects of SO are related to mitochondrial damage and oxidative stress.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carcinógenos
/
Calcio
/
Apoptosis
/
Estrés Oxidativo
/
Citocromos c
/
Compuestos Epoxi
/
Mitocondrias
/
Neuronas
Límite:
Humans
Idioma:
En
Revista:
Toxicology
Año:
2004
Tipo del documento:
Article
País de afiliación:
Suecia
Pais de publicación:
Irlanda