Meningoencephalitis and demyelination are pathologic manifestations of primary polyomavirus infection in immunosuppressed rhesus monkeys.
J Neuropathol Exp Neurol
; 63(7): 750-8, 2004 Jul.
Article
en En
| MEDLINE
| ID: mdl-15290900
The human polyomavirus JC (JCV) is the etiologic agent of progressive multifocal leukoencephalopathy (PML), a demyelinating disease of the CNS that occurs in immunosuppressed individuals. Because polyomavirus-induced CNS pathology usually occurs as a result of the reactivation of latent virus, little is known about the disease manifestations of a primary polyomavirus-induced disease in man. To model such a primary infection, SV40-negative rhesus monkeys were immunosuppressed by infection with the virus SHIV-89.6P and then superinfected with the polyomavirus SV40. The animals developed CNS pathology characterized by both demyelination and meningoencephalitis. This observation suggests that a primary polyomavirus infection can be associated with an inflammatory CNS process. These data shed new light on the pathogenic mechanisms of primate polyomaviruses in the immunocompromised host.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucoencefalopatía Multifocal Progresiva
/
Enfermedades Desmielinizantes
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Virus 40 de los Simios
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Infecciones por Polyomavirus
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Macaca mulatta
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Meningoencefalitis
Límite:
Animals
Idioma:
En
Revista:
J Neuropathol Exp Neurol
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido