Pulmonary tuberculosis: evaluation of interferon-gamma levels as an immunological healing marker based on the response to the Bacillus Calmette-Guerin.
Mem Inst Oswaldo Cruz
; 99(3): 283-7, 2004 May.
Article
en En
| MEDLINE
| ID: mdl-15273801
Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis whose interaction with the host may lead to a cell-mediated protective immune response. The presence of interferon gamma (IFN-gamma) is related to this response. With the purpose of understanding the immunological mechanisms involved in this protection, the lymphoproliferative response, IFN-gamma and other cytokines like interleukin (IL-5, IL-10), and tumor necrosis factor alpha (TNF-alpha) were evaluated before and after the use of anti-TB drugs on 30 patients with active TB disease, 24 healthy household contacts of active TB patients, with positive purified protein derivative (PPD) skin tests (induration > 10 mm), and 34 asymptomatic individuals with negative PPD skin test results (induration < 5 mm). The positive lymphoproliferative response among peripheral blood mononuclear cells of patients showed high levels of IFN-gamma, TNF-alpha, and IL-10. No significant levels of IL-5 were detected. After treatment with rifampicina, isoniazida, and pirazinamida, only the levels of IFN-gamma increased significantly (p < 0.01). These results highlight the need for further evaluation of IFN-gamma production as a healing prognostic of patients treated.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tuberculosis Pulmonar
/
Leucocitos Mononucleares
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Vacuna BCG
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Citocinas
/
Antituberculosos
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
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Adult
/
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
Año:
2004
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil