Dentin regeneration by dental pulp stem cell therapy with recombinant human bone morphogenetic protein 2.
J Dent Res
; 83(8): 590-5, 2004 Aug.
Article
en En
| MEDLINE
| ID: mdl-15271965
Regenerative medicine is based on stem cells, signals, and scaffolds. Dental pulp tissue has the potential to regenerate dentin in response to noxious stimuli, such as caries. The progenitor/stem cells are responsible for this regeneration. Thus, stem cell therapy has considerable promise in dentin regeneration. Culture of porcine pulp cells, as a three-dimensional pellet, promoted odontoblast differentiation compared with monolayers. The expression of dentin sialophosphoprotein (Dspp) and enamelysin/matrix metalloproteinase 20 (MMP20) mRNA confirmed the differentiation of pulp cells into odontoblasts and was stimulated by the morphogenetic signal, bone morphogenetic protein 2 (BMP2). Based on the in vitro experiments, an in vivo evaluation of pulp progenitor/stem cells in the dog was performed. The autogenous transplantation of the BMP2-treated pellet culture onto the amputated pulp stimulated reparative dentin formation. In conclusion, BMP2 can direct pulp progenitor/stem cell differentiation into odontoblasts and result in dentin formation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Regeneración
/
Células Madre
/
Factor de Crecimiento Transformador beta
/
Proteínas Morfogenéticas Óseas
/
Trasplante de Células Madre
/
Pulpa Dental
/
Dentina
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Dent Res
Año:
2004
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Estados Unidos