Linkage disequilibrium between the pseudoautosomal PEPB-1 locus and the sex-determining region of chinook salmon.
Heredity (Edinb)
; 93(1): 85-97, 2004 Jul.
Article
en En
| MEDLINE
| ID: mdl-15218510
Allele frequency differences between sexes and an excess of heterozygotes in males had suggested that the PEPB-1 locus is sex-linked in chinook salmon (Oncorhynchus tshawytscha). We here estimate less than 1% recombination between PEPB-1 and a growth hormone pseudogene known to be in the sex-determining region (SEX) in 374 progeny from eight experimental matings. We present modified maximum likelihood methods for estimating haplotype frequencies from population samples at a sex-linked locus in which functional alleles occur on both the X and Y chromosomes (pseudoautosomal loci). We find nearly complete linkage disequilibrium between PEPB-1 and SEX in 20 population samples from the Puget Sound region of Washington and southern British Columbia. However, allele frequencies at PEPB-1 were similar in males and females in 35 population samples from the coast of Washington and the Columbia River basin. Pseudoautosomal regions have been described in a broad taxonomic array of vertebrates and invertebrates, and they are likely candidate regions to find genes associated with differences in life history, morphology, or behavior between males and females.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Salmón
/
Desequilibrio de Ligamiento
Límite:
Animals
Idioma:
En
Revista:
Heredity (Edinb)
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido