Human leukocyte antigens as genetic markers in Greek patients with sporadic pancreatic cancer.

Kouerinis, I A; Zografos, G; Tarassi, K E; Athanasiades, T H; Liontos, M; Gorgoulis, V G; Korkolis, D; Konstandoulakis, M M; Fotiadis, C I; Androulakis, G; Papasteriades, C A

Kouerinis, I A; Zografos, G; Tarassi, K E; Athanasiades, T H; Liontos, M; Gorgoulis, V G; Korkolis, D; Konstandoulakis, M M; Fotiadis, C I; Androulakis, G; Papasteriades, C A.

Afiliación

Kouerinis IA; First Propaudeutic Surgical Department, School of Medicine, University of Athens, Greece. ikouerinis@hotmail.com

Pancreas ; 29(1): 41-4, 2004 Jul.

Article en En | MEDLINE | ID: mdl-15211110

RESUMEN

PURPOSE: In this study we investigated the relationship between specific HLA antigens and sporadic pancreatic cancer in Greek population. METHODS: The allele frequencies of serologically and molecular defined class I and II HLA antigens were studied in 60 unrelated patients with pancreatic cancer histologically confirmed. The results obtained for HLA frequencies were compared with those of 105 healthy control subjects (control group). RESULTS: Increased frequencies of HLA-A30 (16.7 vs. 3.8%; P < 0.01; OR = 5.05), A31 (9.5 vs. 1.9%; P < 0.05; OR = 5.72), B18 (31.7 vs. 14.3%; P < 0.05; OR = 2.78) and Cw7 (53.3 vs. 21.9%; P < 0.01; OR = 4.07) were observed in patients with pancreatic cancer in comparison to the control subjects. CONCLUSIONS: This study demonstrates the association between specific HLA antigens and pancreatic cancer development in whites and suggests a genetic susceptibility factor for the disease.

Asunto(s)

Antígenos de Neoplasias/análisis; Antígenos HLA/análisis; Neoplasias Pancreáticas/genética; Anciano; Anciano de 80 o más Años; Alcoholismo/epidemiología; Antígenos de Neoplasias/genética; Comorbilidad; Diabetes Mellitus Tipo 2/epidemiología; Femenino; Frecuencia de los Genes; Genes MHC Clase I; Genes MHC Clase II; Marcadores Genéticos; Predisposición Genética a la Enfermedad; Genotipo; Grecia/epidemiología; Antígenos HLA/genética; Antígenos HLA-A/análisis; Antígenos HLA-A/genética; Antígenos HLA-B/análisis; Antígenos HLA-B/genética; Antígeno HLA-B18; Antígenos HLA-C/análisis; Antígenos HLA-C/genética; Prueba de Histocompatibilidad; Humanos; Masculino; Persona de Mediana Edad; Neoplasias Pancreáticas/epidemiología; Neoplasias Pancreáticas/inmunología; Población Blanca/genética

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Antígenos HLA / Antígenos de Neoplasias Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Pancreas Asunto de la revista: GASTROENTEROLOGIA Año: 2004 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Estados Unidos

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