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Importance of the angiotensin type 1 receptor in angiotensin II-induced bronchoconstriction and bronchial hyperresponsiveness in the guinea pig.
Watanabe, Kazuyoshi; Myou, Shigeharu; Fujimura, Masaki; Tachibana, Hideki; Kita, Toshiyuki; Nakao, Sinji.
Afiliación
  • Watanabe K; Division of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa Graduate University School of Medicine, 13-1 Takara-machi, Kanazawa 920-8641, Japan. watanabe@med3.m.kanazawa-u.ac.jp
Exp Lung Res ; 30(3): 207-21, 2004.
Article en En | MEDLINE | ID: mdl-15195554
Although angiotensin II (Ang II) causes bronchoconstriction and bronchial hyperresponsiveness to methacholine in mildly asthmatic patients, the responsible mechanisms for these reactions are unclear. The authors examined the effect of intravenous infusion of Ang II on airway constriction in guinea pigs. Furthermore, the effects of subthreshold concentrations of Ang II on bronchial responsiveness to methacholine were investigated. Airway opening pressure (Pao), an index of bronchoconstriction, increased dose dependently after intravenous infusion of 3 and 10 nmol/kg Ang II (72.2 and 236.5 increase above the baseline value, respectively). In another set of experiments, animals received a methacholine inhalation challenge under a constant intravenous infusion of a subthreshold dose of Ang II (2 nmol/kg/min). The Ang II infusion elicited bronchial hyperresponsiveness to methacholine. The provocative concentration of methacholine, which produced a 200% increase above the baseline Pao (PC200), decreased from 306.9 to 156.1 micrograms/mL upon Ang II infusion. Pretreatment with TCV-116, a type 1 Ang II (AT1) receptor antagonist, but not PD123319, a type 2 Ang II (AT2) receptor antagonist, dose dependently prevented both the Ang II-induced bronchoconstriction and bronchial hyperresponsiveness to methacholine. The authors conclude that Ang II caused bronchoconstriction and induced bronchial hyperresponsiveness to methacholine via the AT1 receptors and that this effect did not involve the release of other bronchoactive mediators.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tetrazoles / Vasoconstrictores / Angiotensina II / Broncoconstricción / Hiperreactividad Bronquial / Receptor de Angiotensina Tipo 1 Límite: Animals Idioma: En Revista: Exp Lung Res Año: 2004 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tetrazoles / Vasoconstrictores / Angiotensina II / Broncoconstricción / Hiperreactividad Bronquial / Receptor de Angiotensina Tipo 1 Límite: Animals Idioma: En Revista: Exp Lung Res Año: 2004 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido