Biosafety aspects of the recombinant live oral Vibrio cholerae vaccine strain CVD 103-HgR.
Vaccine
; 22(19): 2457-69, 2004 Jun 23.
Article
en En
| MEDLINE
| ID: mdl-15193410
The development of live attenuated vaccines, allowing for the safe and effective immunisation at mucosal surfaces, is a strategy of great interest for vaccinologists. The main advantage of this approach over conventional parenteral vaccines is the induction of strong mucosal immune responses, allowing targeting of the pathogen at the initial point of contact with the host. Further advantages include the ease of administration, high acceptance by vaccines, and relatively low production costs. Finally, well-characterised, safe and immunogenic vaccine strains are well suited as vectors for the mucosal delivery of foreign vaccine antigens and of DNA vaccines. However, such vaccines, when based on or containing genetically modified organisms (GMOs), are facing new and specific regulatory hurdles, particularly regarding the potential risks for humans and the environment. In this contribution we address selected aspects of the risk assessment of live attenuated bacterial vaccines covered in the course of the registration of vaccine strain CVD 103-HgR as a recombinant live oral vaccine against cholera.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vibrio cholerae
/
Vacunas contra el Cólera
/
Vacunas Atenuadas
/
Vacunas Sintéticas
/
Cólera
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Vaccine
Año:
2004
Tipo del documento:
Article
País de afiliación:
Suiza
Pais de publicación:
Países Bajos