TREK-1, a K+ channel involved in neuroprotection and general anesthesia.
EMBO J
; 23(13): 2684-95, 2004 Jul 07.
Article
en En
| MEDLINE
| ID: mdl-15175651
TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. It is inhibited by neurotransmitters that produce an increase in intracellular cAMP and by those that activate the Gq protein pathway. TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs. Using mice with a disrupted TREK-1 gene, we now show that TREK-1 has an important role in neuroprotection against epilepsy and brain and spinal chord ischemia. Trek1-/- mice display an increased sensitivity to ischemia and epilepsy. Neuroprotection by polyunsaturated fatty acids, which is impressive in Trek1+/+ mice, disappears in Trek1-/- mice indicating a central role of TREK-1 in this process. Trek1-/- mice are also resistant to anesthesia by volatile anesthetics. TREK-1 emerges as a potential innovative target for developing new therapeutic agents for neurology and anesthesiology.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fármacos Neuroprotectores
/
Anestésicos Generales
/
Canales de Potasio de Dominio Poro en Tándem
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Anestesia General
Límite:
Animals
Idioma:
En
Revista:
EMBO J
Año:
2004
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Reino Unido