Swimming exercise in infancy has beneficial effect on the hearts in cardiomyopathic Syrian hamsters.

Tatsuguchi, Mariko; Hiratsuka, Eriko; Machida, Shuichi; Nishikawa, Toshio; Imamura, Shin-Ichiro; Shimizu, Satoru; Nishimura, Masahiko; Komuro, Issei; Furutani, Yoshiyuki; Furutani, Michiko; Nagao, Hiroaki; Komatsu, Keiko; Kasanuki, Hiroshi; Matsuoka, Rumiko

Tatsuguchi, Mariko; Hiratsuka, Eriko; Machida, Shuichi; Nishikawa, Toshio; Imamura, Shin-Ichiro; Shimizu, Satoru; Nishimura, Masahiko; Komuro, Issei; Furutani, Yoshiyuki; Furutani, Michiko; Nagao, Hiroaki; Komatsu, Keiko; Kasanuki, Hiroshi; Matsuoka, Rumiko.

Afiliación

Tatsuguchi M; Department of Cardiology, Heart Institute of Japan, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.

J Muscle Res Cell Motil ; 25(1): 69-76, 2004.

Article en En | MEDLINE | ID: mdl-15160490

RESUMEN

The phenotypic expression of cardiomyopathy is greatly influenced by extrinsic factors other than intrinsic genetic defects, such as environmental stress. Exercise is assumed to be an important extrinsic factor, since sudden death is sometimes seen during exercise in young patients with hypertrophic cardiomyopathy (HCM). However, the long-term effects of mild exercise on phenotypic expression in cardiomyopathy remain unclear. To evaluate the effects of exercise performed during infancy or adolescence in cardiomyopathic patients, cardiomyopathic Syrian hamsters (BIO14.6) were subjected to swimming. BIO14.6 and age-matched congenic normal hamsters (CN) as controls were divided into three groups: sedentary (Sed), and trained during infancy (Inf) and during adolescence (Ado). Histological and biochemical analysis of 41-week-old hamsters revealed that (1) the relative level of beta-myosin heavy chain mRNA was significantly lower in the Inf group than in the Sed and Ado groups of BIO14.6. The level in the Inf group of BIO14.6 was compatible with that in the age-matched Sed group of the CN strain; (2) in BIO14.6, degenerative mitochondrial change in the cardiomyocytes was not seen in the Inf group while it was common in the Sed and Ado groups; (3) calcineurin phosphatase activity in the swimming group in 10-week-old CN was significantly higher than that of the age-matched sedentary group, and was as much as that of the swimming and sedentary groups in 10- and 41-week-old BIO14.6.

Asunto(s)

Cardiomiopatía Hipertrófica/metabolismo; Ventrículos Cardíacos/fisiopatología; Condicionamiento Físico Animal/fisiología; Natación; Factores de Edad; Animales; Peso Corporal; Cardiomiopatía Hipertrófica/genética; Cardiomiopatía Hipertrófica/patología; Tamaño de la Célula; Cricetinae; Modelos Animales de Enfermedad; Ventrículos Cardíacos/química; Técnicas In Vitro; Mesocricetus; Miocardio/química; Miocardio/metabolismo; Miocardio/patología; Miocitos Cardíacos/metabolismo; Miocitos Cardíacos/ultraestructura; Cadenas Pesadas de Miosina/genética; Tamaño de los Órganos; Monoéster Fosfórico Hidrolasas/metabolismo; ARN Mensajero/análisis; ARN Mensajero/genética; Natación/fisiología; Factores de Tiempo; Función Ventricular; Miosinas Ventriculares/genética

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Natación / Cardiomiopatía Hipertrófica / Ventrículos Cardíacos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Muscle Res Cell Motil Año: 2004 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos

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