Chromosome damaging effects of pan masala.

Jaju, R J; Patel, R K; Bakshi, S R; Trivedi, A H; Dave, B J; Adhvaryu, S G

Jaju, R J; Patel, R K; Bakshi, S R; Trivedi, A H; Dave, B J; Adhvaryu, S G.

Afiliación

Jaju RJ; Cell Biology Division, Gujarat Cancer and Research Institute, Ahmedabad, India.

Cancer Lett ; 65(3): 221-6, 1992 Aug 31.

Article en En | MEDLINE | ID: mdl-1516036

RESUMEN

Effects of aqueous extracts of a popular brand of pan masala with and without tobacco (PM-T and PM) were studied for short duration treatment employing an in vitro system. Metabolic activation with S9 mix was also included. Frequency of all the three cytogenetic endpoints viz., chromosome aberration (CA); sister chromatid exchange (SCE) and % micronucleated cells (% MNC) were found to be elevated significantly in a dose-dependent manner in cultures without metabolic activation. However, addition of S9 activation system resulted in suppression of chromosomal damage. Our findings indicate that pan masalas contain water soluble direct acting mutagens.

Asunto(s)

Areca; Aberraciones Cromosómicas; Mutágenos; Extractos Vegetales/toxicidad; Plantas Medicinales; Intercambio de Cromátides Hermanas; Animales; Células CHO/efectos de los fármacos; Cricetinae; Cricetulus; Activación Enzimática; Hígado/enzimología; Extractos Hepáticos; Pruebas de Micronúcleos; Pruebas de Mutagenicidad

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Areca / Plantas Medicinales / Intercambio de Cromátides Hermanas / Extractos Vegetales / Aberraciones Cromosómicas / Mutágenos Límite: Animals Idioma: En Revista: Cancer Lett Año: 1992 Tipo del documento: Article País de afiliación: India Pais de publicación: Irlanda

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