Evaluation of a recombinant salivary gland protein (thrombostasin) as a vaccine candidate to disrupt blood-feeding by horn flies.
Vaccine
; 22(17-18): 2285-97, 2004 Jun 02.
Article
en En
| MEDLINE
| ID: mdl-15149788
The potential for controlling blood-feeding by the cattle pest, Haematobia irritans irritans (horn fly), was tested by vaccination against thrombostasin (TS), an inhibitor of mammalian thrombin that is released into skin during horn fly blood-feeding. The increase in blood meal size that occurred for flies feeding on sensitized non-vaccinated hosts was blocked and egg development in female flies was delayed when horn flies fed on rabbits and cattle immunized with recombinant TS. This demonstration of the impact of disrupting TS action by vaccination provides a novel approach toward control of this veterinary pest and offers a paradigm for limiting blood-feeding in other medically-important insect species.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Muscidae
/
Vacunas Sintéticas
/
Control de Insectos
/
Proteínas de Insectos
Tipo de estudio:
Evaluation_studies
Límite:
Animals
Idioma:
En
Revista:
Vaccine
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Países Bajos