[The effect of substituting latanoprost 0.005% for unoprostone 0.12%].
Nippon Ganka Gakkai Zasshi
; 108(4): 207-12, 2004 Apr.
Article
en Ja
| MEDLINE
| ID: mdl-15148736
PURPOSE: To evaluate the effect of substituting latanoprost(LAT) 0.005% for unoprostone(UNO) 0.12% after a trial of unilateral treatment. METHODS: We treated 30 patients with primary open-angle glaucoma(n = 8), ocular hypertension (n = 1), or normal-tension glaucoma(n = 21) with UNO for 4 weeks in one eye and then substituted LAT for UNO. Four weeks later we measured the intraocular pressure(IOP) in the ipsilateral eye. RESULTS: The mean baseline IOP level was 18.6 +/- 3.8(mean +/- standard deviation) mmHg. The mean IOP levels(reduction rates) after UNO and LAT therapy were 16.7 +/- 3.1 mmHg (16.6%) and 14.1 +/- 3.2 mmHg (28.9%), respectively(p < 0.001). All patients who responded to UNO also responded to LAT; however, 55% of those who did not respond to UNO responded to LAT. CONCLUSIONS: If LAT is substituted for UNO, it can be predicted that 63.3% of the patients will respond.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Prostaglandinas F Sintéticas
/
Dinoprost
/
Glaucoma
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Glaucoma de Ángulo Abierto
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Hipertensión Ocular
/
Antihipertensivos
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ja
Revista:
Nippon Ganka Gakkai Zasshi
Año:
2004
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Japón