The end-to-side peripheral nerve repair. Functional and morphometric study using the peroneal nerve of rats.
J Neurosci Methods
; 136(1): 45-53, 2004 Jun 15.
Article
en En
| MEDLINE
| ID: mdl-15126044
Morphologic and functional recovery following an end-to-side repair was studied comparatively with conventional end-to-end repair in a model of peroneal nerve lesion in rats. Twenty-eight rats were used and divided into four groups according to the reparative procedure following nerve division: (1) nerve stumps buried into neighboring muscles (n = 8); (2) conventional end-to-end repair (n = 7); (3) end-to-side repair onto the tibial nerve (n = 8); (4) sham operation (n = 5). The sciatic functional index (SFI) was evaluated at weekly intervals for 8 weeks, the peroneal nerve being resected on the 56th day for histologic and morphometric studies. The SFI progressively improved in Groups 2 (-16.9) and 3 (-22.7), although it did not reach normal values (around -8). The average nerve fiber density increased to normal values in both Groups 2 and 3, although accompanied by a marked decrease of average minimal and maximal nerve fiber diameter, myelin sheath area and G quotient. The differences between Groups 2 and 3 or Groups 2 and 4 were not significant. We conclude that, although resulting in significant morphologic and functional recovery, end-to-side repair is not as efficient as the conventional end-to-end nerve repair. However, end-to-side repair has a potential for application in selected cases in humans.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nervio Peroneo
Límite:
Animals
Idioma:
En
Revista:
J Neurosci Methods
Año:
2004
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Países Bajos