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Prognostic significance of cyclooxygenase-2 (COX-2) and expression of cell cycle inhibitors p21 and p27 in human pleural malignant mesothelioma.
Baldi, A; Santini, D; Vasaturo, F; Santini, M; Vicidomini, G; Di Marino, M Pia; Esposito, V; Groeger, A M; Liuzzi, G; Vincenzi, B; Tonini, G; Piccoli, M; Baldi, F; Scarpa, S.
Afiliación
  • Baldi A; Department of Biochemistry and Biophysics, F Cedrangolo, Section of Anatomic Pathology, Second University of Naples, Naples, Italy.alfonsobaldi@tiscali.it
Thorax ; 59(5): 428-33, 2004 May.
Article en En | MEDLINE | ID: mdl-15115874
BACKGROUND: A study was undertaken to analyse the potential prognostic value of the immunohistochemical expression of cyclooxygenase-2 (COX-2) and p27 in 29 malignant mesotheliomas already screened for the expression of p21 and p53. METHODS: Immunohistochemistry was used to determine the expression of COX-2 and p27. The correlation with survival of these factors and of p21 and p53 expression was assessed by univariate and multivariate analyses. RESULTS: A positive statistically significant correlation was found between p27 and p21 expression (p<0.0001), but there was a negative correlation between COX-2 expression and both p27 (p = 0.001) and p21 (p<0.0001). No statistically significant correlation was recorded between p53 and all the other immunohistochemical parameters. Univariate analysis showed that overall survival was strongly influenced by p21, p27, and COX-2 expression, but multivariate Cox regression analysis showed that the only immunohistochemical parameter to influence overall survival of patients with mesothelioma was COX-2. CONCLUSIONS: These findings suggest that COX-2 expression may be a useful prognostic parameter for mesothelioma.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pleurales / Prostaglandina-Endoperóxido Sintasas / Ciclinas / Proteínas de Ciclo Celular / Proteínas Supresoras de Tumor / Isoenzimas / Mesotelioma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Thorax Año: 2004 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pleurales / Prostaglandina-Endoperóxido Sintasas / Ciclinas / Proteínas de Ciclo Celular / Proteínas Supresoras de Tumor / Isoenzimas / Mesotelioma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Thorax Año: 2004 Tipo del documento: Article Pais de publicación: Reino Unido