2-[(18)F]-fluoroisonicotinic acid hydrazide: biological evaluation in an acute infection model.
Appl Radiat Isot
; 60(6): 839-43, 2004 Jun.
Article
en En
| MEDLINE
| ID: mdl-15110348
We have synthesized 2-[(18)F]-fluoroisonicotinic acid hydrazide by nucleophilic displacement reaction on ethyl-2- (trimethylammonium)-isonicotinate precursor in acetonitrile. Kryptofix 222 was used as the phase transfer catalyst. The intermediate fluorinated ethyl ester reacted with hydrazine hydrate to produce the hydrazide. Excellent radiochemical yield was attained with total synthesis time of approximately 60 min. Biological evaluation was performed in bacterial cells and biodistribution in normal as well as E. coli infected CBA/J mice. It was found that the S. pneumoniae cells retained the radiotracer in an in vitro assay. The tracer showed positive localization at the infection/inflammation site in E. coli infected mice.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tuberculosis Pulmonar
/
Radioisótopos de Flúor
/
Infecciones por Escherichia coli
/
Infecciones
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Appl Radiat Isot
Asunto de la revista:
MEDICINA NUCLEAR
/
SAUDE AMBIENTAL
Año:
2004
Tipo del documento:
Article
País de afiliación:
Arabia Saudita
Pais de publicación:
Reino Unido