Association between -250G/A polymorphism of the hepatic lipase gene promoter and coronary artery disease and HDL-C levels in a Southern Brazilian population.

de Andrade, F M; Silveira, F R; Arsand, M; Antunes, A L S; Torres, M R; Zago, A J; Callegari-Jaques, S M; Hutz, M H

de Andrade, F M; Silveira, F R; Arsand, M; Antunes, A L S; Torres, M R; Zago, A J; Callegari-Jaques, S M; Hutz, M H.

Afiliación

de Andrade FM; Departamento de Genética, Instituto de Biociências, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.

Clin Genet ; 65(5): 390-5, 2004 May.

Article en En | MEDLINE | ID: mdl-15099346

RESUMEN

Hepatic lipase (HL) is a glycoprotein that plays a major role in remodeling high-density lipoprotein (HDL). The effect of the -250G/A promoter polymorphism on coronary artery disease (CAD) and lipid levels was studied in 231 male CAD patients and in a population-based sample of men and women (n = 514). A sample of 140 men was chosen among those included in the population-based sample as controls for the CAD sample. In the total group of CAD patients, the frequency of the -250A allele was somewhat lower (25% in CAD patients and 32% in controls; p = 0.06), but when the control samples were compared only with the CAD(+) sample (more than 60% of luminal stenosis in at least one coronary artery or major branch segment) the -250A allele was significantly less frequent (23% in the patients vs 32% in controls; p = 0.02). A multiple logistic regression analysis showed that this association was independent of classical CAD risk factors [odds ratio (OR) = 1.79, p = 0.025]. Using multiple linear regression analyses, it has been shown that this polymorphism was a significant factor affecting HDL-C levels in men from the population-based sample (p = 0.001), an interaction between -250G/A variant and wine consumption was also detected (p = 0.001). Thus, our results show that the -250G/A polymorphism in the HL gene is associated with significant variations in HDL-C levels and CAD risk in males.

Asunto(s)

HDL-Colesterol/sangre; Enfermedad de la Arteria Coronaria/genética; Lipasa/genética; Hígado/enzimología; Polimorfismo de Nucleótido Simple; Adulto; Brasil/etnología; Estudios de Casos y Controles; HDL-Colesterol/genética; Enfermedad de la Arteria Coronaria/sangre; Femenino; Frecuencia de los Genes; Predisposición Genética a la Enfermedad; Genética de Población; Humanos; Masculino; Persona de Mediana Edad; Regiones Promotoras Genéticas; Análisis de Regresión; Población Blanca/genética

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Polimorfismo de Nucleótido Simple / Lipasa / HDL-Colesterol / Hígado Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: Clin Genet Año: 2004 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Dinamarca

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