[Gender has a strong modulating effect on the risk of Alzheimer's disease conferred by the apolipoprotein E gene in the population of the Canary Islands, Spain]. / Fuerte modulacion de genero sobre el riesgo conferido por el gen de la apolipoproteina E para la enfermedad de Alzheimer en la poblacion de las Islas Canarias, España.
Rev Neurol
; 38(7): 615-8, 2004.
Article
en Es
| MEDLINE
| ID: mdl-15098180
OBJECTIVES: Apolipoprotein E (ApoE) gen has been found to confer risk for Alzheimer disease in every population studied. We are interested in analyzed the exonic variants and the promoter polymorphisms in our Canary population. SUBJECTS AND METHODS: By means of PCR RFLP analysis of DNA from patients (NINCS ADRDA criteria) and controls (cognitive state CAMCOG test measured) we analyzed the known exonic and promoter polymorphism of ApoE gen. RESULTS: We have found an association of Alzheimer disease risk based on exonic variants of ApoE gen, with a clear cut dose effect on susceptibility and no risk conferred by the promoter polymorphisms. Age at onset are not affected by variants of ApoE gen, and patients gender strongly modulate the disease susceptibility. CONCLUSION: We have found in our Canary population an association between Alzheimer disease with exonic variants of ApoE gen with a strong modulation by the patients gender.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Apolipoproteínas E
/
Factores Sexuales
/
Enfermedad de Alzheimer
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Aspecto:
Determinantes_sociais_saude
Límite:
Aged
/
Female
/
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
Es
Revista:
Rev Neurol
Año:
2004
Tipo del documento:
Article
Pais de publicación:
España