Development of 99mTc labelled Lipiodol: biodistribution following injection into the hepatic artery of the healthy pig.
Nucl Med Commun
; 25(3): 291-7, 2004 Mar.
Article
en En
| MEDLINE
| ID: mdl-15094449
BACKGROUND: We develop a method for the radiolabelling of Lipiodol with Tc, using a lipophilic complex, [99mTc-(S2CPh)(S3Ph)2], dissolved in Lipiodol (99mTc-SSS Lipiodol). RESULTS: The labelling yield is high (96 +/- 0.8%), and the radiochemical purity satisfactory (92 +/- 2.6%). This labelling is reproducible and stable for up to 24 h in vitro. Studies carried out after injection into the hepatic artery of the healthy pig show that the biodistribution of 99mTc-SSS Lipiodol is comparable with that observed for 188Re Lipiodol. MATERIALS AND METHODS: The 99mTc-SSS lipiodol was obtained after dissolving a chelating agent, previously labelled with 99mTc, in cold lipiodol. The radiochemical purity (RCP) of the labelling was checked immediately and at 24 h. The 99mTc-SSS lipiodol was injected into the hepatic artery of four healthy pigs for an ex-vivo biodistribution study. An autoradiographic study was performed in two cases. CONCLUSIONS: Apart from the specific interest of a Lipiodol-bearing technetiated agent for carrying out dosimetric studies, the labelling of Lipiodol with 99mTc is a preliminary step towards the use of radiolabelling with the 188Re analogue.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tecnecio
/
Aceite Yodado
/
Arteria Hepática
/
Marcaje Isotópico
Tipo de estudio:
Evaluation_studies
Límite:
Animals
Idioma:
En
Revista:
Nucl Med Commun
Año:
2004
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Reino Unido