Deposits in artificial corneas: risk factors and prevention.
Clin Exp Ophthalmol
; 32(2): 185-91, 2004 Apr.
Article
en En
| MEDLINE
| ID: mdl-15068437
PURPOSE: To identify risk factors for calcium deposition and pigmented staining within AlphaCor artificial corneas. METHODS: Retrospective analysis of data from 72 AlphaCor implantations was conducted. Histological analysis of explants was performed. RESULTS: Eight cases of either intraoptic calcium or pigment deposition occurred in AlphaCor patients between 2.5 and 21 months after implantation. Four cases had diffuse white deposits, confirmed to be calcium and associated with prior coadministration of topical steroids and beta-blockers. The other four cases had brown deposits, associated with cigarette smoking and topical levobunolol. CONCLUSION: These findings led to changes in patient management protocols, surgeon training and patient information so as to minimize the risk of further occurrences. No further cases of white deposition have occurred after warning surgeons of the risk associated with certain topical therapy combinations. The risk of brown staining may be difficult to remove completely as it appears that environmental exposure to chemicals may cause deposition in addition to personal smoking habits and topical medications.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos de la Pigmentación
/
Órganos Artificiales
/
Calcinosis
/
Córnea
Tipo de estudio:
Etiology_studies
/
Guideline
/
Observational_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Clin Exp Ophthalmol
Asunto de la revista:
OFTALMOLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Australia
Pais de publicación:
Australia