Population pharmacokinetics of imipramine in children.
Eur J Clin Pharmacol
; 43(1): 89-92, 1992.
Article
en En
| MEDLINE
| ID: mdl-1505617
ABSTRACT
PIP: Researchers used population pharmacokinetic parameters and data on the concentration effect relationship from 49 6-13 year old children suffering from enuresis who attended an outpatient psychiatric clinic at University Clinical Hospital in Salamanca, Spain to design rational dosing guidelines of the antidepressant imipramine (IMI) for individual patients. They evaluated 177 IMI serum levels and IMI's active metabolite desipramine (DMI) serum levels. The researchers used standard 2-stage (STS) and maximum likelihood methods to conduct the population pharmacokinetic analysis of IMI. They used STS to simultaneously estimate IMI and DMI parameters. The average value of IMI's elimination constant stood at 0.0425 h-1 and that of DMI's elimination constant stood at 0.0359 h-1. The researchers observed more variability in pharmacokinetic parameters of DMI than those of IMI. Based on estimated pharmacokinetic parameters, a dose of 1.7 mg kg-1 day-1 IMI is needed in children to reach the total serum level of 80 ng/ml which was higher than the dose generally administered in clinical practice (1 mg kg-1 day-1). The researchers demonstrated that applying the population pharmacokinetic parameters to Bayesian fitting methods allows clinicians to individualize IMI dose in children.
Palabras clave
Age Factors; Biology; Child; Clinical Research; Delivery Of Health Care; Demographic Factors; Depression--prevention and control; Developed Countries; Diseases; Drugs--pharmacodynamics; Europe; Examinations And Diagnoses; Health; Health Facilities; Hematologic Tests; Laboratory Examinations And Diagnoses; Laboratory Procedures; Mediterranean Countries; Mental Disorders; Methodological Studies; Outpatient Clinic; Physiology; Population; Population Characteristics; Research Methodology; Southern Europe; Spain; Treatment; Urogenital Effects; Urogenital System; Youth
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Imipramina
Tipo de estudio:
Guideline
/
Prognostic_studies
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Eur J Clin Pharmacol
Año:
1992
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Alemania