Sarcoma of follicular dendritic cells in the dorsal mediastinum.
Hum Pathol
; 35(2): 259-63, 2004 Feb.
Article
en En
| MEDLINE
| ID: mdl-14991546
Follicular dendritic cell sarcomas (FDCSs) are very rare and usually originate in lymph nodes. We report an exceedingly rare case with localization in the dorsal mediastinum and, for the first time, provide positron emission tomography (PET) data for this tumor. This report describes the case of a 76-year-old man with a clinically aggressive tumor in the dorsal mediastinum. Computed tomography scan revealed displacement of soft tissue and lymph nodes. PET showed that the tumor had a high proliferation rate. Investigation of the successfully removed tumor mass revealed reactivity of the tumor cells for follicular dendritic cell markers and desmosomes linking adjacent tumor cells at the ultrastructural level. Marked atypia, a high mitotic rate, and areas of coagulative necrosis were found. The tumor in our case revealed the typical features and thus was classified as FDCS. In contrast to previous reports in the literature, preoperative imaging, histology, and immunohistochemistry studies indicated at least an intermediate degree of malignancy. Nevertheless, the patient made a good postoperative recovery and remained apparently disease-free 2 years later.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sarcoma
/
Células Dendríticas Foliculares
/
Neoplasias del Mediastino
Límite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Hum Pathol
Asunto de la revista:
PATOLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Estados Unidos