[Interrelations between the content of reactive oxygen species and the state of DNA structure in bone marrow cells of mice after whole body gamma-irradiation]. / Vzaimosviaz' soderzhaniia aktivnykh form kisloroda i sostoianiia struktury DNK v kletkakh kostnogo mozga u myshei v dinamike posle obshchego vozdeistviia gamma-izlucheniia.
Radiats Biol Radioecol
; 43(6): 625-32, 2003.
Article
en Ru
| MEDLINE
| ID: mdl-14963928
The aim of the research is a further analysis of a problem concerning two (regulatory and damaging) functions of reactive oxygen species (ROS) in viability of organism cells under acute exposure to ionizing radiation. For this purpose the ROS content and the state of DNA structure in bone marrow cells of male CBA and SHK mice have been studied in dynamics, from 15 minutes up to 185 day after acute exposure to a sublethal dose (1.5 Gy) of ionizing radiation. The analysis of dependencies between these parameters in the norm, immediately after irradiation and in later cell descendants showed the direct correlation between the ROS content and the DNA nativity in the norm; 185 days after irradiation the correlation disappeared. It was suggested that the correlation occurred in the norm indicates participation of the ROS (as a sensory link) in a system of reactions (under the control of the corresponding genetic program), that ensure the DNA structure and, ultimately, the genome stability. The loss of such connection after acute exposure to ionizing radiation indicates actuation of another module of reactions sustaining stability of cellular genome in new conditions, without regulatory participation of ROS, that can promote or demonstrate the development of radiation-induced genome instability.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADN
/
Células de la Médula Ósea
/
Especies Reactivas de Oxígeno
/
Inestabilidad Genómica
/
Rayos gamma
Límite:
Animals
Idioma:
Ru
Revista:
Radiats Biol Radioecol
Asunto de la revista:
GENETICA
/
MEDICINA NUCLEAR
Año:
2003
Tipo del documento:
Article
Pais de publicación:
Rusia