HPLC-methods for determination of lipoic acid and its reduced form in human plasma.

Teichert, J; Preiss, R

Teichert, J; Preiss, R.

Afiliación

Teichert J; Institute of Clinical Pharmacology, University of Leipzig, Germany.

Int J Clin Pharmacol Ther Toxicol ; 30(11): 511-2, 1992 Nov.

Article en En | MEDLINE | ID: mdl-1490813

RESUMEN

A method has been developed for the HPLC analysis of lipoic acid and its reduced form (dihydrolipoic acid) in biological samples. Both substances are released from the samples by enzymatic hydrolysis and extracted by solid phase column. The extracts, after evaporation, were chromatographed and quantified by electrochemical detection. The basic level was in the range 1-25 ng/ml for lipoic acid and 33-145 ng/ml for dihydrolipoic acid (6 healthy volunteers).

Asunto(s)

Ácido Tióctico/sangre; Cromatografía Líquida de Alta Presión; Electroquímica; Humanos; Hidrólisis; Masculino; Oxidación-Reducción; Ácido Tióctico/análogos & derivados

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Tióctico Límite: Humans / Male Idioma: En Revista: Int J Clin Pharmacol Ther Toxicol Año: 1992 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania

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