The influence of tetrodotoxin on the toxic effects of aconitine in vivo.

Ohno, Y; Chiba, S; Uchigasaki, S; Uchima, E; Nagamori, H; Mizugaki, M; Ohyama, Y; Kimura, K; Suzuki, Y

Ohno, Y; Chiba, S; Uchigasaki, S; Uchima, E; Nagamori, H; Mizugaki, M; Ohyama, Y; Kimura, K; Suzuki, Y.

Afiliación

Ohno Y; Department of Legal Medicine, Nippon Medical School, Tokyo.

Tohoku J Exp Med ; 167(2): 155-8, 1992 Jun.

Article en En | MEDLINE | ID: mdl-1475787

RESUMEN

Both aconite toxins (aconitine, mesaconitine, and hypaconitine) and a pufferfish toxin (tetrodotoxin, TTX) were detected in the blood of a legal autopsy case. In order to elucidate the in vivo influence of TTX on the toxic effects of aconitine, a mixture of aconitine and TTX was administered to male ICR mice orally or intraperitoneally. The animal experiments revealed that the time of death due to aconitine was significantly delayed in proportion to the dose of TTX compared with the case for aconitine alone, and that the mortality of aconitine was lowered by TTX when the dose ratio of the two toxins was in a particular range. Accordingly, it is thought that the toxic effects of aconitine are attenuated by TTX in vivo.

Asunto(s)

Aconitina/envenenamiento; Tetrodotoxina/farmacología; Aconitina/antagonistas & inhibidores; Aconitina/toxicidad; Adulto; Animales; Relación Dosis-Respuesta a Droga; Femenino; Humanos; Masculino; Ratones; Ratones Endogámicos ICR; Tetrodotoxina/administración & dosificación

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tetrodotoxina / Aconitina Límite: Adult / Animals / Female / Humans / Male Idioma: En Revista: Tohoku J Exp Med Año: 1992 Tipo del documento: Article Pais de publicación: Japón

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