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Aquaporin-1 expression in human glial tumors suggests a potential novel therapeutic target for tumor-associated edema.
Oshio, K; Binder, D K; Bollen, A; Verkman, A S; Berger, M S; Manley, G T.
Afiliación
  • Oshio K; Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA.
Acta Neurochir Suppl ; 86: 499-502, 2003.
Article en En | MEDLINE | ID: mdl-14753494
Aquaporins are membrane proteins involved in water transport in many fluid-transporting tissues. The objective of this study was to investigate the expression of aquaporins in malignant glial tumors associated with cerebral edema. Eighteen human glial tumors were obtained from the UCSF Neurosurgery Tissue Bank. Aquaporin-1 (AQP1) expression was evaluated via Western blot and immunohistochemistry. Intense upregulation of AQP1 expression was found in all glioblastomas. The robust expression of aquaporins in glioblastomas suggests a pathologic role for these membrane water channels, and raises the possibility that selective AQP inhibition might offer a new therapeutic option for tumor-associated cerebral edema.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Edema Encefálico / Neoplasias Encefálicas / Acuaporinas / Glioma Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Acta Neurochir Suppl Año: 2003 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Austria
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Edema Encefálico / Neoplasias Encefálicas / Acuaporinas / Glioma Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Acta Neurochir Suppl Año: 2003 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Austria