Identification of HLA alleles with low or no cell surface expression in the Czech population.

Bendukidze, N; Ivasková, E; Zahlavová, L; Slavcev, A; Kupková, L; Sajdlová, H; Day, S; Dunn, P P J

Bendukidze, N; Ivasková, E; Zahlavová, L; Slavcev, A; Kupková, L; Sajdlová, H; Day, S; Dunn, P P J.

Afiliación

Bendukidze N; Department of Immunogenetics, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic. nina.bendukidze@nhs.nbs.uk

Folia Biol (Praha) ; 49(6): 227-9, 2003.

Article en En | MEDLINE | ID: mdl-14748437

RESUMEN

The presence of the A*24020102L allele is implicated in one donor from the CBMD who serologically was typed as A2; B44, B55; Cwl, Cw7. The DRB4*01030102N allele was identified in one healthy donor and in one patient with MDS during routine HLA class II DNA typing. The DRB4*01030102N allele was identified in the patient's father, who had CML, and was associated with the HLA-A3-B7-Cw7-DRB1*0701-DQB1*0303 haplotype, which is common for European populations. In order to avoid mistyping, both techniques, serology and molecular biology must be used for HLA typing, especially for cases where just one antigen appeared to be present using serological methods.

Asunto(s)

Regulación de la Expresión Génica/inmunología; Antígenos HLA/genética; Alelos; Membrana Celular/inmunología; República Checa; Antígenos HLA-D/genética; Antígenos de Histocompatibilidad Clase I/genética; Humanos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Antígenos HLA Tipo de estudio: Diagnostic_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Folia Biol (Praha) Año: 2003 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: República Checa

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