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The endoproteolytic processing of alphavbeta5 integrin is involved in cytoskeleton remodelling and cell migration.
Berthet, Virginie; Rigot, Véronique; Nejjari, Mimoun; Marvaldi, Jacques; Luis, José.
Afiliación
  • Berthet V; CNRS UMR6032, Faculté de Pharmacie, 27 Bd J. Moulin, 13385 Marseille Cedex 5, France.
FEBS Lett ; 557(1-3): 159-63, 2004 Jan 16.
Article en En | MEDLINE | ID: mdl-14741360
We previously showed that the post-translational cleavage of alphav subunit is essential for integrin-dependent signalling and cell adhesion. Here, we report that blocking alphav subunit cleavage by expression of alpha1-PDX, a convertase inhibitor, modified the capacity of cells to change shape, via a remodelling of the actin cytoskeleton upon cell attachment. These changes are associated with cell scattering and with a dramatic increase in cell migration to vitronectin. The alphav subunit cleavage is thus essential for integrin function and has a considerable impact on integrin-dependent events, especially those leading to cell migration.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citoesqueleto / Integrinas / Movimiento Celular / Receptores de Vitronectina Límite: Humans Idioma: En Revista: FEBS Lett Año: 2004 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citoesqueleto / Integrinas / Movimiento Celular / Receptores de Vitronectina Límite: Humans Idioma: En Revista: FEBS Lett Año: 2004 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido