3-(2-pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity human 5-HT(1B/1D) ligands.

Egle, Ian; MacLean, Neil; Demchyshyn, Lidia; Edwards, Louise; Slassi, Abdelmalik; Tehim, Ashok

Egle, Ian; MacLean, Neil; Demchyshyn, Lidia; Edwards, Louise; Slassi, Abdelmalik; Tehim, Ashok.

Afiliación

Egle I; NPS Pharmaceuticals Inc, 6850 Goreway Dr, Mississauga, Ontario, Canada L4V 1V7. iegle@npsp.com

Bioorg Med Chem Lett ; 14(3): 727-9, 2004 Feb 09.

Article en En | MEDLINE | ID: mdl-14741277

RESUMEN

A series of 3-(2-pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives (2) has been prepared using parallel synthesis techniques, and their structure-activity relationships studied. High affinity human 5-HT(1B/1D) (h5-HT(1B/1D)) ligands have been identified.

Asunto(s)

Indoles/química; Indoles/metabolismo; Piridinas/química; Piridinas/metabolismo; Receptor de Serotonina 5-HT1B/metabolismo; Humanos; Ligandos; Relación Estructura-Actividad

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridinas / Receptor de Serotonina 5-HT1B / Indoles Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2004 Tipo del documento: Article Pais de publicación: Reino Unido

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