Dopamine transporter binding in Gilles de la Tourette syndrome: a [123I]FP-CIT/SPECT study.

Serra-Mestres, J; Ring, H A; Costa, D C; Gacinovic, S; Walker, Z; Lees, A J; Robertson, M M; Trimble, M R

Serra-Mestres, J; Ring, H A; Costa, D C; Gacinovic, S; Walker, Z; Lees, A J; Robertson, M M; Trimble, M R.

Afiliación

Serra-Mestres J; Department of Neuropsychiatry, Institute of Neurology, University College London, UK. jordi.serra-mestres@thh.nhs.uk

Acta Psychiatr Scand ; 109(2): 140-6, 2004 Feb.

Article en En | MEDLINE | ID: mdl-14725596

RESUMEN

OBJECTIVE: To investigate dopamine transporter binding in Gilles de la Tourette syndrome (GTS) with SPECT and [123I]FP-CIT. METHOD: Ten neuroleptic naïve/free patients with GTS, and 10 age- and gender-matched normal volunteers were studied. Subjects were clinically evaluated. GTS severity and affective symptoms were measured and the presence of GTS-related behaviours were recorded. RESULTS: The GTS group showed significantly higher binding in both caudate and putamen nuclei than the controls. No associations were found between striatal binding ratios and measures of affect or GTS-related behaviours. CONCLUSION: Patients with GTS show higher striatal binding of FP-CIT to the striatum in comparison with age- and gender-matched control subjects, indicating that dopamine transporter abnormalities are involved in the pathophysiology of GTS. These abnormalities appear to be distributed across both caudate and putamen.

Asunto(s)

Dopamina/metabolismo; Glicoproteínas de Membrana; Proteínas de Transporte de Membrana/metabolismo; Proteínas del Tejido Nervioso/metabolismo; Radiofármacos; Síndrome de Tourette/metabolismo; Adolescente; Adulto; Cuerpo Estriado/diagnóstico por imagen; Proteínas de Transporte de Dopamina a través de la Membrana Plasmática; Femenino; Humanos; Radioisótopos de Yodo; Masculino; Persona de Mediana Edad; Putamen/diagnóstico por imagen; Tomografía Computarizada de Emisión de Fotón Único; Síndrome de Tourette/diagnóstico por imagen; Tropanos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Transporte de Membrana / Glicoproteínas de Membrana / Dopamina / Síndrome de Tourette / Radiofármacos / Proteínas del Tejido Nervioso Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Psychiatr Scand Año: 2004 Tipo del documento: Article Pais de publicación: Estados Unidos

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