Mutations of the BRAF gene in benign and malignant melanocytic lesions.
J Invest Dermatol
; 121(5): 1160-2, 2003 Nov.
Article
en En
| MEDLINE
| ID: mdl-14708620
A single-point mutation in exon 15 of the BRAF gene has recently been reported in a high percentage in cultured melanoma cells and in 6 of 9 primary melanomas examined. To evaluate the impact of the T1796A BRAF mutation, we screened primary melanomas, various types of nevi and lesions where a melanoma developed in an underlying nevus. We could detect the mutation in 28 of 97 (29%) melanomas and in 39 of 187 (21%) nevi, including blue nevi (0/20) and Spitz nevi (0/69), which did not carry the mutation. In melanomas with an underlying nevus, either the mutation was present in both the laser-microdissected nevus cells and the laser-microdissected melanoma cells (3/14) or both lesions were negative for the BRAF mutation except one case. In conclusion, mutations in exon 15 of the BRAF gene are nonspecific for progression of a nevus to a melanoma. Other so far unknown cofactors seem to be of importance.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Mutación Puntual
/
Proteínas Proto-Oncogénicas c-raf
/
Melanoma
/
Nevo
Límite:
Humans
Idioma:
En
Revista:
J Invest Dermatol
Año:
2003
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Estados Unidos