Dramatic improvement with clonidine in acute pancreatitis with elevated catecholamine and cortisol plasma levels: report of five cases.

Lechin, F; van der Dijs, B; Lechin, M; Jara, H; Lechin, A; Cabrera, A; Rada, I; Orozco, B; Jiménez, V; Valderrama, T

Lechin, F; van der Dijs, B; Lechin, M; Jara, H; Lechin, A; Cabrera, A; Rada, I; Orozco, B; Jiménez, V; Valderrama, T.

Afiliación

Lechin F; Section of Gastroenterology, Institute of Experimental Medicine, School of Medicine, Central University of Venezuela.

J Med ; 23(5): 339-51, 1992.

Article en En | MEDLINE | ID: mdl-1469335

RESUMEN

We report five cases of patients with acute pancreatitis (AP) resistant to conventional treatment who improved dramatically with clonidine. All patients showed greatly elevated plasma levels of noradrenaline (norepinephrine) (NA), adrenalin (epinephrine) (Ad) and cortisol (CRT), physiologic indicators of stress, which decreased abruptly upon initiation of clonidine therapy. The clonidine test performed in the patients showed a hyper-response in all, a reaction consistent with uncoping stress situations. Therefore, we postulate that stress might play a role in the pathogenesis of pancreatic inflammatory disease in these patients.

Asunto(s)

Clonidina/uso terapéutico; Pancreatitis/tratamiento farmacológico; Enfermedad Aguda; Adulto; Catecolaminas/sangre; Femenino; Humanos; Hidrocortisona/sangre; Masculino; Pancreatitis/sangre

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pancreatitis / Clonidina Límite: Adult / Female / Humans / Male Idioma: En Revista: J Med Año: 1992 Tipo del documento: Article Pais de publicación: Estados Unidos

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