A new approach to the synthesis of benzothiazole, benzoxazole, and pyridine nucleosides as potential antitumor agents.

Khodair, Ahmed I; Al-Masoudi, Najim A; Gesson, Jean-Pierre

Khodair, Ahmed I; Al-Masoudi, Najim A; Gesson, Jean-Pierre.

Afiliación

Khodair AI; Chemistry Department, Faculty of Education, Tanta University (Kafr El-Sheikh Branch), Kafr El-Sheikh, Egypt. khodair_62@yahoo.com

Nucleosides Nucleotides Nucleic Acids ; 22(11): 2061-76, 2003 Nov.

Article en En | MEDLINE | ID: mdl-14680028

RESUMEN

A modified nitrogen and sulfur glycosylation reaction involving benzothiazole benzoxazole and pyridine nucleoside bases with furanose and pyranose sugars are described. Conformational analysis has been studied by homo- and heteronuclear two-dimensional NMR methods (2D DFQ-COSY, HMQC and HMBC). The N and S sites of glycosylation were determined from the 1H, 13C heteronuclear multiple-quantum coherence (HMQC) experiments. All the deprotected nucleosides were tested for their potential antitumor activity.

Asunto(s)

Antineoplásicos/síntesis química; Benzoxazoles/química; Nucleósidos/síntesis química; Piridinas/química; Tiazoles/química; Antineoplásicos/química; Antineoplásicos/farmacología; Benzotiazoles; Benzoxazoles/síntesis química; Benzoxazoles/farmacología; Línea Celular Tumoral; Humanos; Nucleósidos/química; Nucleósidos/farmacología; Tiazoles/síntesis química; Tiazoles/farmacología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridinas / Tiazoles / Benzoxazoles / Antineoplásicos / Nucleósidos Límite: Humans Idioma: En Revista: Nucleosides Nucleotides Nucleic Acids Asunto de la revista: BIOQUIMICA Año: 2003 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Estados Unidos

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