Treatment of chronic intractable neuropathic pain with dronabinol: case report of two adolescents.
Pain Res Manag
; 8(4): 221-4, 2003.
Article
en En
| MEDLINE
| ID: mdl-14679417
OBJECTIVE: To evaluate the effectiveness of dronabinol for the treatment of neuropathic pain refractory to previous treatment. METHODS: We studied the response (reduction of pain intensity and functional improvement) to dronabinol (5 mg/day to 25 mg/day) in two adolescents with neuropathic pain and depression refractory to previous treatments over two and five years, respectively. RESULTS: Reduction in pain intensity (45%) was achieved in patient 2 and was unchanged in patient 1. Functional improvement was markedly increased in terms of academic performance, mood and sleep in both patients over four to five months, without major adverse effects. While these improvements dissipated over time, the patients were more reconnected with rehabilitation and focused less on the intrusiveness of their pain problem in their every day lives. CONCLUSIONS: Dronabinol appeared to be effective in improving pain affect and psychosocial functioning in the treatment of refractory neuropathic pain and may be considered as an adjuvant medication in the rehabilitation process. Well-controlled placebo studies are required for further evaluation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dolor
/
Dronabinol
/
Analgésicos no Narcóticos
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Pain Res Manag
Asunto de la revista:
NEUROLOGIA
/
PSICOFISIOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Estados Unidos