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Localization of mechanosensitive channel TRPV4 in mouse skin.
Suzuki, Makoto; Watanabe, Yuko; Oyama, Yuki; Mizuno, Atsuko; Kusano, Eiji; Hirao, Atsushi; Ookawara, Shigeo.
Afiliación
  • Suzuki M; Department of Pharmacology, Jichi Medical School, Kawachi, Tochigi 329-0498, Japan. macsuz@jichi.ac.jp
Neurosci Lett ; 353(3): 189-92, 2003 Dec 26.
Article en En | MEDLINE | ID: mdl-14665413
A transient receptor potential (TRP) family, TRPV4, is a calcium-permeable swell-activated channel, playing a role in cutaneous mechanosensation. To elucidate the localization in the mechanosensitive endings, we found with immunohistochemistry in mice that TRPV4 was expressed both by small (low threshold) and large (high threshold) dorsal root ganglia neurons. In addition to free nerve endings, TRPV4 was specifically located at cutaneous mechanosensory terminals co-localized with neurofilament 200, including Meissner, Merkel, penicillate and intraepidermal terminals but not including hair follicle palisades. The distribution suggests that the sensation of pressure by mechanosensitive TRPV4 channel is transmitted through A- as well as C-fiber.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Glicoproteínas de Membrana / Proteínas de Transporte de Catión / Canales Iónicos Límite: Animals Idioma: En Revista: Neurosci Lett Año: 2003 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Irlanda
Buscar en Google
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Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Glicoproteínas de Membrana / Proteínas de Transporte de Catión / Canales Iónicos Límite: Animals Idioma: En Revista: Neurosci Lett Año: 2003 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Irlanda