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Kinetics of bone marrow eosinophilopoiesis and associated cytokines after allergen inhalation.
Dorman, Sandra C; Sehmi, Roma; Gauvreau, Gail M; Watson, Rick M; Foley, Ronan; Jones, Graham L; Denburg, Judah A; Inman, Mark D; O'Byrne, Paul M.
Afiliación
  • Dorman SC; Asthma Research Group, Firestone Institute for Respiratory Health, St. Joseph's Healthcare, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Am J Respir Crit Care Med ; 169(5): 565-72, 2004 Mar 01.
Article en En | MEDLINE | ID: mdl-14656753
Allergen inhalation is associated with increased eosinophil/basophil progenitors in bone marrow 24 hours after allergen inhalation. This study examined the kinetics of eosinophilopoiesis in dual (n = 14), compared with isolated early, responders (n = 12). Dual responders, in contrast to isolated early responders, develop significant sputum and blood eosinophilia and prolonged airway hyperresponsiveness. Bone marrow aspirates were taken before and 5, 12, 24, and 48 hours after allergen inhalation. In dual responders, increases in interleukin (IL)-3-responsive progenitors were detected as early as 5 hours after allergen inhalation, and IL-5-responsive progenitors were detected at 12 and 24 hours. No changes were detected in isolated early responders. Bone marrow IL-5 protein levels increased at 12 and 24 hours in dual responders only and these increases correlated with increases in IL-5-responsive progenitors. In addition, bone marrow IFN-gamma levels increased in dual responders at 48 hours. These data demonstrate that, in dual responders, there is allergen-induced activation of an eosinophilopoietic process that is rapid and sustained, and a relationship between increased bone marrow IL-5 levels and increased eosinophil production. We propose that after allergen inhalation, time-dependent changes in cytokine levels in the bone marrow control differentiation of eosinophil/basophil progenitors.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Eosinofilia Pulmonar / Asma / Médula Ósea / Citocinas / Eosinófilos / Hematopoyesis Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Respir Crit Care Med Asunto de la revista: TERAPIA INTENSIVA Año: 2004 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Buscar en Google
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Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Eosinofilia Pulmonar / Asma / Médula Ósea / Citocinas / Eosinófilos / Hematopoyesis Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Respir Crit Care Med Asunto de la revista: TERAPIA INTENSIVA Año: 2004 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos