Synthesis and anti-measles virus activity of new isoquinolin-4-one derivatives.
Farmaco
; 58(12): 1217-25, 2003 Dec.
Article
en En
| MEDLINE
| ID: mdl-14630231
Despite intense efforts to increase vaccine coverage, measles virus (MV) still causes significant morbidity and mortality in the world sometimes as a results of severe, chronic and lethal diseases. In an effort to develop therapies to supplement immunization strategies a number of 1-oxo-2-[[(1E)-phenylmethylene]amino]-1,2-dihydroisoquinoline-4-carboxylic acid derivatives were synthesized and evaluated for anti-measles activity. The substituents on the aromatic ring were chosen in order to evaluate the influence of electron-withdrawing or electron-donating effects on the electronic density of the aromatic moiety. We also evaluated the introduction of a vinyl chain between the exocyclic nitrogen and phenyl moiety. The biological results allow to outline some preliminary considerations on structure-activity relationship.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Isoquinolinas
/
Virus del Sarampión
Idioma:
En
Revista:
Farmaco
Asunto de la revista:
FARMACOLOGIA
/
QUIMICA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Francia