Occult tumor cell contamination in patients with stage II/III breast cancer receiving sequential high-dose chemotherapy.

Viret, F; Chabannon, C; Sainty, D; Genre, D; Gonçalves, A; Arnoulet, C; Gravis, G; Bertucci, F; Houvenaeghel, G; Jacquemier, J; Bardou, V J; Ladaique, P; Braud, A C; Maraninchi, D; Viens, P

Viret, F; Chabannon, C; Sainty, D; Genre, D; Gonçalves, A; Arnoulet, C; Gravis, G; Bertucci, F; Houvenaeghel, G; Jacquemier, J; Bardou, V J; Ladaique, P; Braud, A C; Maraninchi, D; Viens, P.

Afiliación

Viret F; Department of Medicine, Institut Paoli-Calmettes, Marseille, France. viretf@marseille.fnclcc.fr

Bone Marrow Transplant ; 32(11): 1059-64, 2003 Dec.

Article en En | MEDLINE | ID: mdl-14625576

RESUMEN

The purpose of this study was to evaluate the presence of micrometastatic cells in the apheresis products from patients with breast cancer, and also to determine if repeated infusion of contaminated products had any clinical impact. A total of 94 patients with high-risk breast cancer were enrolled in a prospective single center study to evaluate the use of dose-intensified chemotherapy (doxorubicine 75 mg/m(2) and cyclophosphamide 3000 or 6000 mg/m(2) for four cycles) with repeated (x 2) stem cell reinfusion. All women were monitored for the presence of metastatic cells in aphereses, collected after first course of intensive chemotherapy, and following additional mobilization with rhG-CSF. Epithelial cells were screened with monoclonal antibodies directed to cytokeratin. Eight of the 94 patients had detectable tumor cells in one or several aphereses collected after intensive chemotherapy; this was unrelated to other tumor characteristics, including size, histology, Scarff Bloom and Richardson (SBR) grading (presence or absence of hormone receptors). Hemato-poietic reconstitution was similar in the cells from these eight patients, and in the total patient population. Three of these eight patients relapsed. This study has confirmed that contamination of apheresis products remains a rare event, which does not seem to affect clinical evolution, even when reinfused into the patient.

Asunto(s)

Protocolos de Quimioterapia Combinada Antineoplásica/administración & dosificación; Eliminación de Componentes Sanguíneos/efectos adversos; Neoplasias de la Mama/terapia; Células Neoplásicas Circulantes/patología; Adulto; Protocolos de Quimioterapia Combinada Antineoplásica/toxicidad; Eliminación de Componentes Sanguíneos/normas; Neoplasias de la Mama/mortalidad; Neoplasias de la Mama/patología; Recuento de Células; Ciclofosfamida/administración & dosificación; Relación Dosis-Respuesta a Droga; Doxorrubicina/administración & dosificación; Femenino; Movilización de Célula Madre Hematopoyética; Trasplante de Células Madre Hematopoyéticas/efectos adversos; Trasplante de Células Madre Hematopoyéticas/normas; Humanos; Persona de Mediana Edad; Metástasis de la Neoplasia/patología; Estudios Prospectivos; Análisis de Supervivencia; Resultado del Tratamiento

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Eliminación de Componentes Sanguíneos / Neoplasias de la Mama / Protocolos de Quimioterapia Combinada Antineoplásica / Células Neoplásicas Circulantes Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Bone Marrow Transplant Asunto de la revista: TRANSPLANTE Año: 2003 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido

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