In vivo calibration of the subcutaneous amperometric glucose sensors using a non-enzyme electrode.
Biosens Bioelectron
; 19(4): 313-9, 2003 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-14615088
A new two-point calibration method for the subcutaneous amperometric continuous glucose sensor is reported. The proposed method is based on direct measurement of the background current (I(o)) using a non-enzyme electrode. For in vivo test, three electrodes were implanted in rabbits. Two of the three were identical needle-type enzyme electrodes with perfluorinated polymer outer layers (Pt/enzyme layer/Kel-F/PTFE/Kel-F/Nafion) that were placed in subcutaneous tissue and in a vessel (ear artery), respectively. And one non-enzyme electrode with exactly the same membrane composition as those of other two was in the subcutaneous layer to measure the background current. Implantation in the subcutaneous layer generated many crevices on the protecting layers of the electrodes. The signals from enzyme electrodes were effectively corrected by the measured background current from the non-enzyme electrode. In addition, a telemetric monitoring system was developed and evaluated for in vivo continuous glucose monitoring in order to alleviate the problems of motion artifact.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Prótesis e Implantes
/
Glucemia
/
Algoritmos
/
Técnicas Biosensibles
/
Automonitorización de la Glucosa Sanguínea
/
Monitoreo Ambulatorio
/
Electroquímica
/
Electrodos
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Biosens Bioelectron
Asunto de la revista:
BIOTECNOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Corea del Sur
Pais de publicación:
Reino Unido