Functional imbalance of visual pathways indicates alternative face processing strategies in autism.
Neurology
; 61(9): 1232-7, 2003 Nov 11.
Article
en En
| MEDLINE
| ID: mdl-14610126
OBJECTIVE: To investigate whether autistic subjects show a different pattern of neural activity than healthy individuals during processing of faces and complex patterns. METHODS: Blood oxygen level-dependent (BOLD) signal changes accompanying visual processing of faces and complex patterns were analyzed in an autistic group (n = 7; 25.3 [6.9] years) and a control group (n = 7; 27.7 [7.8] years). RESULTS: Compared with unaffected subjects, autistic subjects demonstrated lower BOLD signals in the fusiform gyrus, most prominently during face processing, and higher signals in the more object-related medial occipital gyrus. Further signal increases in autistic subjects vs controls were found in regions highly important for visual search: the superior parietal lobule and the medial frontal gyrus, where the frontal eye fields are located. CONCLUSIONS: The cortical activation pattern during face processing indicates deficits in the face-specific regions, with higher activations in regions involved in visual search. These findings reflect different strategies for visual processing, supporting models that propose a predisposition to local rather than global modes of information processing in autism.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Reconocimiento Visual de Modelos
/
Trastorno Autístico
/
Vías Visuales
/
Cara
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Neurology
Año:
2003
Tipo del documento:
Article
País de afiliación:
Suiza
Pais de publicación:
Estados Unidos