Female reproductive factors and open angle glaucoma: the Blue Mountains Eye Study.
Br J Ophthalmol
; 87(11): 1324-8, 2003 Nov.
Article
en En
| MEDLINE
| ID: mdl-14609824
AIMS: To determine whether endogenous oestrogen exposures are associated with open angle glaucoma (OAG). METHODS: The Blue Mountains Eye Study examined 2072 women aged 49-97 years during 1992-4. Questions about female reproductive factors included age at menarche and menopause, parity, and use of hormone replacement therapy. Applanation tonometry, visual field tests, and stereo-optic disc photographs were performed. OAG was diagnosed when glaucomatous visual fields matched optic disc changes. Ocular hypertension (OH) was defined in the absence of glaucoma, but with intraocular pressure >or=22 mm Hg. RESULTS: A significantly increased OAG risk with later (>13 years) compared with earlier (or=50 years), adjusted OR = 1.7; CI: 0.7 to 3.8, and for shorter duration of endogenous oestrogen exposure (<30 years), adjusted OR = 1.8; CI: 0.6 to 5.3. Increasing parity was associated with an increased risk of OAG (p = 0.03) and decreased risk of OH (p = 0.03). CONCLUSION: The modest associations found in relation to late menarche and increased parity do not allow the exclusion of a possible role for endogenous female hormones in the pathogenesis of OAG.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glaucoma de Ángulo Abierto
/
Estrógenos
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Aged
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Aged80
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Female
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Humans
/
Middle aged
País/Región como asunto:
Oceania
Idioma:
En
Revista:
Br J Ophthalmol
Año:
2003
Tipo del documento:
Article
País de afiliación:
Australia
Pais de publicación:
Reino Unido