Right ventricle of patients undergoing congenital cardiac surgery differentially expresses haem oxygenase-1 and heat shock protein 70 genes.
J Int Med Res
; 31(5): 413-7, 2003.
Article
en En
| MEDLINE
| ID: mdl-14587309
Reactive oxygen species are implicated in the pathogenesis of cardiac hypertrophy. Haem oxygenase-1 (HO-1), the rate-limiting enzyme in haem catabolism, is induced by oxidative stress and confers protection against oxidative tissue injuries. We used Northern blotting to examine expression of HO-1 and heat shock protein 70 (HSP70) in the hypertrophic cardiac muscle of eight patients (one infant and seven children) who underwent surgery for congenital heart disease. Levels of HO-1 and HSP70 mRNA were significantly increased in all specimens, but the orders of magnitude of the increases were different, suggesting that the genes expressing HO-1 and HSP70 are regulated separately.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas HSP70 de Choque Térmico
/
Cardiopatías
/
Ventrículos Cardíacos
/
Hemo Oxigenasa (Desciclizante)
Límite:
Child, preschool
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Female
/
Humans
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Infant
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Male
Idioma:
En
Revista:
J Int Med Res
Año:
2003
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Reino Unido