Manadomanzamines A and B: a novel alkaloid ring system with potent activity against mycobacteria and HIV-1.
J Am Chem Soc
; 125(44): 13382-6, 2003 Nov 05.
Article
en En
| MEDLINE
| ID: mdl-14583033
Two novel alkaloids, named manadomanzamines A (1) and B (2), were isolated from an Indonesian sponge Acanthostrongylophora sp. (Haplosclerida: Petrosiidae). Their structures were elucidated and shown to be a novel organic skeleton related to the manzamine type alkaloids. Their absolute configuration and conformation were determined by CD, NOESY, and molecular modeling analysis. The microbial community analysis for the sponge that produces these unprecedented alkaloids has also been completed. Manadomanzamines A (1) and B (2) exhibited strong activity against Mycobacterium tuberculosis (Mtb) with MIC values of 1.9 and 1.5 mug/mL, respectively. Manadomanzamines A and B also exhibit activities against human immunodeficiency virus (HIV-1) and AIDS opportunistic fungal infections.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
VIH-1
/
Alcaloides Indólicos
/
Alcaloides
/
Mycobacterium tuberculosis
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Am Chem Soc
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos